> In **recurrent asthma, airway remodeling may occur**. All of the following describe the pathophysiological changes that occur in the airways, EXCEPT: > 1. Hyperplasia and hypertrophy of bronchial smooth muscle 2. An increase in the number of fibroblasts and hence fibrosis 3. **An increase in the number of afferent (sensory) neurons…** 4. An increase in the number and activity of mucus secreting cells and glands
Question
In recurrent asthma, airway remodeling may occur. All of the following describe the pathophysiological changes that occur in the airways, EXCEPT:
- Hyperplasia and hypertrophy of bronchial smooth muscle
- An increase in the number of fibroblasts and hence fibrosis
- An increase in the number of afferent (sensory) neurons…
- An increase in the number and activity of mucus secreting cells and glands
Solution
The correct answer is 3. An increase in the number of afferent (sensory) neurons. This statement does not describe a pathophysiological change that occurs in the airways during recurrent asthma. The other options (1, 2, and 4) are all changes that can occur due to airway remodeling in recurrent asthma. These include hyperplasia and hypertrophy of bronchial smooth muscle, an increase in the number of fibroblasts leading to fibrosis, and an increase in the number and activity of mucus-secreting cells and glands. However, an increase in sensory neurons is not a typical feature of airway remodeling in asthma.
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