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A 29-year-old woman is brought to the emergency room after falling off her third floor apartment balcony. The patient suffered blunt abdominal trauma, a right femur fracture, and a left humeral fracture. On physical examination, her blood pressure is 70/30 mmHg and her heart rate is 120 beats per minute. After the administration of 5 units of packed red blood cells, the patient reports a “pins and needles” sensation on her distal toes and around her mouth. Laboratory testing confirms a calcium level of 6.9 mg/dL and a magnesium level of 1.1 mEq/L. Which of the following is the underlying cause of this patient's hypocalcemia and hypomagnesemia?

Question

A 29-year-old woman is brought to the emergency room after falling off her third floor apartment balcony. The patient suffered blunt abdominal trauma, a right femur fracture, and a left humeral fracture. On physical examination, her blood pressure is 70/30 mmHg and her heart rate is 120 beats per minute. After the administration of 5 units of packed red blood cells, the patient reports a “pins and needles” sensation on her distal toes and around her mouth. Laboratory testing confirms a calcium level of 6.9 mg/dL and a magnesium level of 1.1 mEq/L. Which of the following is the underlying cause of this patient's hypocalcemia and hypomagnesemia?

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Solution

The patient's hypocalcemia and hypomagnesemia are likely due to massive blood transfusion. Massive transfusion is defined as the replacement of a patient's total blood volume in less than 24 hours, or as the acute administration of more than half the patient's total blood volume per hour.

When large volumes of packed red blood cells are transfused rapidly, the citrate preservative in the blood binds calcium and magnesium, leading to lower levels of these ions in the blood. This is because citrate is a chelating agent, which means it can bind to metal ions, including calcium and magnesium.

In the liver, citrate is normally metabolized to bicarbonate, and the calcium and magnesium are released back into the bloodstream. However, in situations of massive transfusion, the liver may not be able to metabolize all the citrate, leading to citrate toxicity and resulting in hypocalcemia and hypomagnesemia.

The symptoms of hypocalcemia can include a "pins and needles" sensation, which the patient reported. Other symptoms can include muscle cramps, spasms, and tetany. Hypomagnesemia can cause similar symptoms, as well as nausea, vomiting, and weakness.

In this patient, the hypocalcemia and hypomagnesemia would be treated by slowing the rate of transfusion and administering calcium and magnesium supplements.

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