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A 68-year-old male presented to the primary care physician for his annual visit. His past medical history was significant for mildly elevated blood pressure during the prior annual visit. He was in good health, otherwise. He was advised to reduce salt intake and increase physical activity during that visit. On physical examination, his blood pressure is 178/72 mm Hg, with no clinically significant differences between arms or on standing. He has a body mass index of 28.4 kg/m2 (normal: 18-25 kg/m2). The examination is otherwise unremarkable. Urinalysis is normal. The nonfasting blood glucose level is 95 mg/dL (normal: 80-100 mg/dL), serum potassium is 4.2 mEq/L (normal: 3.5-5 mEq/L), and creatinine is 1.2 mg/dL (normal: 0.7-1.4 mg/dL). Which of the following high blood pressure-related conditions would he most likely have?

Question

A 68-year-old male presented to the primary care physician for his annual visit. His past medical history was significant for mildly elevated blood pressure during the prior annual visit. He was in good health, otherwise. He was advised to reduce salt intake and increase physical activity during that visit. On physical examination, his blood pressure is 178/72 mm Hg, with no clinically significant differences between arms or on standing. He has a body mass index of 28.4 kg/m2 (normal: 18-25 kg/m2). The examination is otherwise unremarkable. Urinalysis is normal. The nonfasting blood glucose level is 95 mg/dL (normal: 80-100 mg/dL), serum potassium is 4.2 mEq/L (normal: 3.5-5 mEq/L), and creatinine is 1.2 mg/dL (normal: 0.7-1.4 mg/dL). Which of the following high blood pressure-related conditions would he most likely have?

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Solution

The patient's presentation is consistent with primary (essential) hypertension. This is the most common type of hypertension, affecting about 95% of patients. It is a diagnosis of exclusion, made when secondary causes (eg, renal disease, hyperaldosteronism, pheochromocytoma, coarctation of the aorta) have been ruled out. In this patient, the normal serum potassium, creatinine, and urinalysis make renal disease and hyperaldosteronism unlikely. His blood pressure is significantly elevated, but there are no symptoms or signs of end-organ damage (eg, left ventricular hypertrophy, retinopathy), which would suggest a secondary cause. Therefore, primary hypertension is the most likely diagnosis.

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