A 64-year-old woman is brought to the emergency department due to fever, chills, flank pain, and lethargy for the past 2 days. Temperature is 38.9 C (102 F), blood pressure is 100/60 mm Hg, and pulse is 120/min. The patient has right costovertebral angle tenderness. Leukocytes are 16,000/mm3 and urinalysis shows pyuria, many bacteria, and positive nitrites. ECG shows sinus tachycardia. A central venous catheter placement is planned for intravenous therapy and hemodynamic monitoring. After the patient's chest is appropriately prepared and draped, a needle is inserted just lateral to the angle of the left clavicle and a triple lumen catheter is placed into the left subclavian vein. Each lumen is flushed with sterile saline after obtaining blood return. The catheter is sutured in place to the skin and a sterile dressing is applied. Which of the following is the best next step in management of this patient?
Question
A 64-year-old woman is brought to the emergency department due to fever, chills, flank pain, and lethargy for the past 2 days. Temperature is 38.9 C (102 F), blood pressure is 100/60 mm Hg, and pulse is 120/min. The patient has right costovertebral angle tenderness. Leukocytes are 16,000/mm3 and urinalysis shows pyuria, many bacteria, and positive nitrites. ECG shows sinus tachycardia. A central venous catheter placement is planned for intravenous therapy and hemodynamic monitoring. After the patient's chest is appropriately prepared and draped, a needle is inserted just lateral to the angle of the left clavicle and a triple lumen catheter is placed into the left subclavian vein. Each lumen is flushed with sterile saline after obtaining blood return. The catheter is sutured in place to the skin and a sterile dressing is applied. Which of the following is the best next step in management of this patient?
Solution
The best next step in the management of this patient would be to start her on empiric antibiotic therapy. Given her symptoms of fever, chills, flank pain, and lethargy, along with the physical exam finding of costovertebral angle tenderness and the lab findings of leukocytosis, pyuria, bacteriuria, and positive nitrites, she likely has pyelonephritis. This is a severe urinary tract infection that has ascended to the kidneys.
Empiric antibiotic therapy should be started as soon as possible to cover the most likely pathogens, which are usually gram-negative rods such as E. coli. The antibiotic regimen can be adjusted later if necessary based on the results of urine and blood cultures.
In addition to antibiotics, the patient should be given fluids to maintain hydration and manage any sepsis, and her vital signs should be closely monitored. She may also need pain management for her flank pain.
The placement of the central venous catheter will allow for the administration of intravenous antibiotics and fluids, and will also allow for close monitoring of her hemodynamic status.
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