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Which one of the following statements is INCORRECT? Question 9Select one:a.The regulatory units of PKA bind cyclic AMP and are released from the PKA complex to phosphorylate downstream signalling molecules.b.Protein kinase A (PKA) contains regulatory and catalytic sub-units.c.Peptide hormones cannot diffuse through the cell membrane.d.Heat shock proteins are chaperone molecules that complex with cytoplasmic steroid hormone receptors.   e.Steroid hormones are synthesised from cholesterol that is largely (80%) transported from the liver and enters target cells following Apo B-100 activation of LDL receptors.

Question

Which one of the following statements is INCORRECT? Question 9Select one:a.The regulatory units of PKA bind cyclic AMP and are released from the PKA complex to phosphorylate downstream signalling molecules.b.Protein kinase A (PKA) contains regulatory and catalytic sub-units.c.Peptide hormones cannot diffuse through the cell membrane.d.Heat shock proteins are chaperone molecules that complex with cytoplasmic steroid hormone receptors.   e.Steroid hormones are synthesised from cholesterol that is largely (80%) transported from the liver and enters target cells following Apo B-100 activation of LDL receptors.

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Solution

The incorrect statement is a. The regulatory units of PKA bind cyclic AMP and are released from the PKA complex to phosphorylate downstream signalling molecules. This is incorrect because when the regulatory subunits of PKA bind to cyclic AMP, they do not get released to phosphorylate downstream signalling molecules. Instead, they undergo a conformational change that releases the catalytic subunits. These catalytic subunits are then free to phosphorylate downstream signalling molecules.

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