People with kidney disease experience many negative health conditions, including weak and brittle bones. Why does this occur? Group of answer choicesIncreased body water due to loss of urine outputAltered toxin load causing metabolic inhibitionDecreased blood pressure that increases hydrostatic forces in bone cellsAnemia leading to decreased oxygenation of bone cellsImpaired activation of vitamin D that is required for bone mineralization
Question
People with kidney disease experience many negative health conditions, including weak and brittle bones. Why does this occur? Group of answer choicesIncreased body water due to loss of urine outputAltered toxin load causing metabolic inhibitionDecreased blood pressure that increases hydrostatic forces in bone cellsAnemia leading to decreased oxygenation of bone cellsImpaired activation of vitamin D that is required for bone mineralization
Solution
People with kidney disease often experience weak and brittle bones due to impaired activation of vitamin D that is required for bone mineralization.
Here's a step-by-step explanation:
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The kidneys play a crucial role in maintaining the balance of calcium and phosphate in the body, which are essential for bone health.
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One of the ways they do this is by converting inactive vitamin D from the diet or skin into its active form, calcitriol.
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Calcitriol helps the body absorb calcium and phosphate from the gut and reabsorb them in the kidneys, preventing their loss in urine.
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It also works with parathyroid hormone (PTH) to regulate the release of calcium and phosphate from the bones to the blood.
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In kidney disease, the kidneys' ability to activate vitamin D is impaired.
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This leads to lower levels of calcitriol, resulting in decreased absorption of calcium and phosphate in the gut and their increased loss in urine.
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The body responds by increasing the production of PTH to release more calcium and phosphate from the bones to the blood.
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Over time, this high PTH level (secondary hyperparathyroidism) can lead to bone disease (renal osteodystrophy), characterized by weak and brittle bones.
So, the main reason why people with kidney disease experience weak and brittle bones is the impaired activation of vitamin D that is required for bone mineralization.
Similar Questions
Osteomalacia…….Question 28Select one:a.usually occurs as a result of bone formation being greater than bone resorption.b.is largely due to defects in Vitamin D metabolism and maintenance of normal calcium levels.c.results in strong bones that rarely fracture.d.is characterised by increased bone growth and mineralisation.e.in most cases is due to immobilization.
________ is a condition associated with vitamin D deficiency in adults that is characterized by softening of the bones.Multiple ChoiceOsteomalaciaMelaninRicketsOsteoporosis
Effector: Synergistically, PTH and calcitriol (vitamin D) increase low blood calcium levels. Osteoclast activity is stimulated by PTH, which promotes bone release and resorption of calcium into the blood (Khan et al., 2022). Furthermore, PTH stimulates the kidneys to convert vitamin D from inactive to active form, calcitriol. This will encourage calcium absorption in the small intestine, increasing blood calcium levels. Together, these mechanisms elevate calcium levels in the blood and restore calcium homeostasis. Increased calcium levels in the serum act as a negative feedback loop, signalling the parathyroid glands to stop the release of PTH is this statement correct?
Impaired kidney function can have an impact on the presence of adequate levels of which vitamin stored in the body?Multiple choice question.DAEK
What is the role of vitamin D in bone development?Multiple choice question.Vitamin D increases osteoclastic activity and thus helps to break down the bone matrix.Vitamin D decreases calcium absorption through the small intestine and thus prevents excess calcium in the blood which could result in deformed bones.Vitamin D increases calcium absorption in the small intestine and thus helps maintain the calcium concentrations necessary to build the bone matrix.
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