When ADH (Antidiuretic Hormone) binds to the receptors on the surface of the cells that make up the wall of the collecting duct, Aquaporin-2 water channels are inserted into the plasma membranes of these cells.

Here are the steps:

1. ADH is released from the posterior pituitary gland in response to dehydration or high blood osmolarity.
2. ADH travels in the bloodstream to the kidneys.
3. ADH binds to V2 receptors on the basolateral membrane of the principal cells in the collecting duct.
4. This binding triggers a signal transduction pathway involving cAMP (cyclic adenosine monophosphate).
5. The increase in cAMP leads to the activation of protein kinase A (PKA).
6. PKA phosphorylates aquaporin-2 water channels that are stored in vesicles within the cell.
7. These phosphorylated aquaporin-2 channels are then inserted into the apical membrane of the cell.
8. This allows water to move from the lumen of the collecting duct, through the cells, and into the interstitial fluid, thus concentrating the urine.

Question

When ADH (Antidiuretic Hormone) binds to the receptors on the surface of the cells that make up the wall of the collecting duct, Aquaporin-2 water channels are inserted into the plasma membranes of these cells.

Here are the steps:

1. ADH is released from the posterior pituitary gland in response to dehydration or high blood osmolarity.
2. ADH travels in the bloodstream to the kidneys.
3. ADH binds to V2 receptors on the basolateral membrane of the principal cells in the collecting duct.
4. This binding triggers a signal transduction pathway involving cAMP (cyclic adenosine monophosphate).
5. The increase in cAMP leads to the activation of protein kinase A (PKA).
6. PKA phosphorylates aquaporin-2 water channels that are stored in vesicles within the cell.
7. These phosphorylated aquaporin-2 channels are then inserted into the apical membrane of the cell.
8. This allows water to move from the lumen of the collecting duct, through the cells, and into the interstitial fluid, thus concentrating the urine.

Knowee AI · Accepted Answer

When ADH (Antidiuretic Hormone) binds to the receptors on the surface of the cells that make up the wall of the collecting duct, Aquaporin-2 water channels are inserted into the plasma membranes of these cells.

Here are the steps:

1. ADH is released from the posterior pituitary gland in response to dehydration or high blood osmolarity.
2. ADH travels in the bloodstream to the kidneys.
3. ADH binds to V2 receptors on the basolateral membrane of the principal cells in the collecting duct.
4. This binding triggers a signal transduction pathway involving cAMP (cyclic adenosine monophosphate).
5. The increase in cAMP leads to the activation of protein kinase A (PKA).
6. PKA phosphorylates aquaporin-2 water channels that are stored in vesicles within the cell.
7. These phosphorylated aquaporin-2 channels are then inserted into the apical membrane of the cell.
8. This allows water to move from the lumen of the collecting duct, through the cells, and into the interstitial fluid, thus concentrating the urine.

What is inserted into the plasma membranes of the cells that make up the wall of the collecting duct when ADH binds the receptors on their surface?

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