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Which one of the following statements about genetic differences (polymorphisms) influencing drug behaviour is INCORRECT?Group of answer choicesPolymorphisms in a gene encoding a protein may have no consequences for protein function.Polymorphisms in enzymes that metabolise drugs are rare.Polymorphisms in a receptor gene might lead to changes in drug binding to that receptor.Polymorphisms in a receptor gene might lead to changes in the ability of the receptor to initiate cell activation following drug binding.

Question

Which one of the following statements about genetic differences (polymorphisms) influencing drug behaviour is INCORRECT?Group of answer choicesPolymorphisms in a gene encoding a protein may have no consequences for protein function.Polymorphisms in enzymes that metabolise drugs are rare.Polymorphisms in a receptor gene might lead to changes in drug binding to that receptor.Polymorphisms in a receptor gene might lead to changes in the ability of the receptor to initiate cell activation following drug binding.

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Solution

The incorrect statement is: "Polymorphisms in enzymes that metabolise drugs are rare."

Explanation: Polymorphisms, or genetic variations, in enzymes that metabolize drugs are not rare. In fact, they are quite common and can significantly influence a person's response to a drug. These polymorphisms can affect the rate at which a drug is metabolized and eliminated from the body, which can in turn affect the drug's efficacy and the risk of side effects. This is a major factor in pharmacogenomics, the study of how genes affect a person's response to drugs.

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