Which sequence is typically found in the core promoter of eukaryotic genes?
Question
Which sequence is typically found in the core promoter of eukaryotic genes?
Solution
The sequence typically found in the core promoter of eukaryotic genes is the TATA box. This sequence, which is usually TATAAA or a variant of it, is located about 25-30 base pairs upstream of the transcription start site. The TATA box is recognized and bound by the TATA-binding protein (TBP), a subunit of the transcription factor II D (TFIID). This binding helps to position the RNA polymerase II correctly at the transcription start site, and serves as a nucleation site for the assembly of the rest of the transcription machinery.
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