Whichof the following processes in the differentiation of the B-cell lineage takesplace primarily in the lymph nodes (as opposed to the bone marrow)?1 pointremovalof the gene regions coding for the γ (G class) heavy chain constant domains synthesisof immunoglobulin membrane receptors with surrogate light chains up-regulationand initial transcription of the genes for Igα and Igβ allelicexclusion of κ genes in cells using a λ light chain gene N-nucleotideaddition at the junction of heavy chainV and D gene region

Whichof the following processes in the differentiation of the B-cell lineage takesplace primarily in the bone marrow (as opposed to the lymph nodes)?1 point removalof the gene regions coding for the mand δ heavy chain constant domains mutationdirected to the variable domain regions specifying the structures of the CDRloops negativeselection to remove B cells that recognize self-antigen activationof B cells by foreign antigen rearrangementof the genes that code for T-cell receptors

T and B cells undergo the development and maturation process in ______.

Whichof these choices indicates the correct order of possible events in B-celldevelopment between the synthesis of Ig α and β and the synapse between theB-cell and the T cell.I. synthesisof surrogate light chainsII. synthesisof m (M class) heavychainsIII. synthesisof δ (D class) heavy chainsIV. synthesisof κ light chainsV. negative selection again self-recognitionnegative selectionagain self-recognition

After arrival of antigen in lymphoid tissue and the activation of resident B cells, which of the following processes does NOT occur in the lymphoid follicles?Select one alternative:Isotype switching of B cells to change the Fc region of the antibody that will be produced.Affinity maturation of the B cells to produce antibody of the highest affinity for the antigen.Migration of B cells into T cell rich areas of the follicle to receive T cell help.Clonal proliferation to produce an "army" of identical B cells with the same antigen-binding specificity.

B – lymphocytes are associated with