Which of the following are advantages of suppositories and inserts as dosage forms? Select all that apply. A. large doses or irritating drugs can be given by suppository B. a suppository is such a dignified way to administer a drug C. a suppository avoids first pass effect and gastrointestinal degradation of the drug D. suppositories can be expelled by defecation E. commercially prepared suppositories are available in fewer dose levels F. administration of unpleasant tasting/smelling drugs is possible, especially for children
Question
Which of the following are advantages of suppositories and inserts as dosage forms?
Select all that apply.
A. large doses or irritating drugs can be given by suppository
B. a suppository is such a dignified way to administer a drug
C. a suppository avoids first pass effect and gastrointestinal degradation of the drug
D. suppositories can be expelled by defecation
E. commercially prepared suppositories are available in fewer dose levels
F. administration of unpleasant tasting/smelling drugs is possible, especially for children
Solution
The advantages of suppositories and inserts as dosage forms from the options provided are:
A. Large doses or irritating drugs can be given by suppository: This is true. Suppositories can be used to administer large doses of medication or drugs that may be irritating if taken orally.
C. A suppository avoids first pass effect and gastrointestinal degradation of the drug: This is also true. The first pass effect refers to the liver's ability to metabolize drugs before they reach systemic circulation. Suppositories bypass the liver, avoiding this effect and also preventing the drug from being degraded by the gastrointestinal system.
F. Administration of unpleasant tasting/smelling drugs is possible, especially for children: This is another advantage of suppositories. They can be used to administer drugs that have an unpleasant taste or smell, making them particularly useful for children who may refuse to take certain medications orally.
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