Which of the following is NOT a manifestation of AGEs effect on blood vessels?a. Endothelial dysfunctionb. Smooth muscle proliferationc. LDL trappingd. Decreased permeabilitye. Increased ECM deposition in their walls
Question
Which of the following is NOT a manifestation of AGEs effect on blood vessels?a. Endothelial dysfunctionb. Smooth muscle proliferationc. LDL trappingd. Decreased permeabilitye. Increased ECM deposition in their walls
Solution
The question is asking which of the given options is NOT a manifestation of Advanced Glycation End-products (AGEs) effect on blood vessels.
a. Endothelial dysfunction - This is a manifestation of AGEs effect on blood vessels. AGEs can cause damage to the endothelium, the inner lining of blood vessels.
b. Smooth muscle proliferation - This is also a manifestation of AGEs effect on blood vessels. AGEs can stimulate the proliferation of smooth muscle cells in the blood vessels.
c. LDL trapping - This is another manifestation of AGEs effect on blood vessels. AGEs can lead to the trapping of low-density lipoprotein (LDL) in the blood vessels.
d. Decreased permeability - This is NOT a manifestation of AGEs effect on blood vessels. In fact, AGEs typically increase the permeability of blood vessels, not decrease it.
e. Increased ECM deposition in their walls - This is a manifestation of AGEs effect on blood vessels. AGEs can lead to increased deposition of extracellular matrix (ECM) in the walls of blood vessels.
So, the correct answer is d. Decreased permeability.
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