Which of the following antimicrobial drugs can be inactivated by beta-lactamase?SELECT ALL THAT APPLYClavulanateAugmentinMeropenemAmoxicillinStreptomycinChloramphenicol
Question
Which of the following antimicrobial drugs can be inactivated by beta-lactamase?SELECT ALL THAT APPLYClavulanateAugmentinMeropenemAmoxicillinStreptomycinChloramphenicol
Solution
Beta-lactamase is an enzyme produced by some bacteria that provides resistance to certain antibiotics, specifically the beta-lactam antibiotics. The antibiotics that can be inactivated by beta-lactamase include:
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Augmentin: This is a combination of amoxicillin and clavulanate. While amoxicillin can be inactivated by beta-lactamase, clavulanate is a beta-lactamase inhibitor. Therefore, Augmentin as a whole is not inactivated by beta-lactamase because the clavulanate component protects the amoxicillin.
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Amoxicillin: This is a beta-lactam antibiotic and can be inactivated by beta-lactamase.
The other drugs listed - Clavulanate, Meropenem, Streptomycin, and Chloramphenicol - are not inactivated by beta-lactamase. Clavulanate is a beta-lactamase inhibitor, Meropenem is a carbapenem that is resistant to beta-lactamase, and Streptomycin and Chloramphenicol are not beta-lactam antibiotics, so they are not affected by beta-lactamase.
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