Question 201 ptsWhich of the following mechanisms is involved in long-term depression (LTD) in the cerebellum?Group of answer choicesactivation of metabotropic glutamate receptorsa reduction in Ca2+ concentration in Purkinje cell dendritesinactivation of Protein Kinase Csensitisation of NMDA receptorssensitisation of AMPA receptors Previous
Question
Question 201 ptsWhich of the following mechanisms is involved in long-term depression (LTD) in the cerebellum?Group of answer choicesactivation of metabotropic glutamate receptorsa reduction in Ca2+ concentration in Purkinje cell dendritesinactivation of Protein Kinase Csensitisation of NMDA receptorssensitisation of AMPA receptors Previous
Solution
Long-term depression (LTD) in the cerebellum is a process that contributes to synaptic plasticity, which is the ability of synapses to strengthen or weaken over time. This process is crucial for learning and memory.
The mechanism involved in LTD in the cerebellum is the activation of metabotropic glutamate receptors. Here's a step-by-step explanation:
-
Glutamate, a neurotransmitter, is released from the presynaptic neuron.
-
This glutamate binds to and activates metabotropic glutamate receptors (mGluRs) on the postsynaptic neuron, which in this case is a Purkinje cell in the cerebellum.
-
The activation of mGluRs leads to an increase in intracellular calcium (Ca2+) concentration in the Purkinje cell dendrites.
-
This increase in Ca2+ concentration triggers a series of intracellular events, including the activation of protein phosphatases.
-
These protein phosphatases then dephosphorylate AMPA receptors, which are ionotropic glutamate receptors.
-
The dephosphorylation of AMPA receptors results in their internalization or removal from the synaptic membrane.
-
This removal of AMPA receptors from the synaptic membrane decreases the sensitivity of the synapse to glutamate, thereby reducing synaptic strength. This is the process of long-term depression (LTD).
So, the correct answer to your question is "activation of metabotropic glutamate receptors".
Similar Questions
Which of the following is NOT involved in the induction of long-term depression in Purkinje cells in the cerebellum?Group of answer choicesActivation of NMDA receptorsActivation of parallel fibresActivation of metabotropic glutamate receptorsActivation of AMPA receptorsActivation of climbing fibres
Long-term depression in mammalian brain does not:Group of answer choicescause reversal of long-term potentiation in some neuronsinvolve a stimulus-dependent increase in excitatory postsynaptic potential (EPSP)become induced following changes in intracellular Ca++ in some neuronspersist for at least 60 minutes following inductioncontribute to motor learning in the cerebellum
role of cerebellum
Which of the following is a major function of the cerebellum?Group of answer choicesAlter local circuits of the brainstem and spinal cord via direct projections to the lower motor neuronsAnalyze errors between intended motor output and actual motor outputModulate the output of the basal gangliaRelay information from the primary somatosensory cortex to the primary motor cortexModulate and relay executive decision-making information from the prefrontal cortex to the rest of the cerebral cortex
A secondary consequence of NMDA receptor antagonism is _______ presynaptic glutamate release, which may result from _______ of receptors on inhibitory GABAergic interneurons that innervate the cortical neurons. Group of answer choicesdecreased; blockadedecreased; openingincreased; blockadeincreased; opening
Upgrade your grade with Knowee
Get personalized homework help. Review tough concepts in more detail, or go deeper into your topic by exploring other relevant questions.