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Jason went to the doctor with a complaint of a yellowish skin and also yellowish colour in the whites of his eyes (sclera). The doctor ordered the following tests.serum bilirubin      205 micro-mol/Lconjugated bilirubin   7 micro-mol/LAST 18 U/L (ref: 12 - 48)ALT  9 U/L  (3 - 55)ALP  77 U/L (30-130)urine bilirubin negativeWhat do you think is the likely cause?Question 9Select one:a.haemolytic anaemiab.obstructive jaundicec.malariad.hepatitis Ae.gallstone

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Jason went to the doctor with a complaint of a yellowish skin and also yellowish colour in the whites of his eyes (sclera). The doctor ordered the following tests.serum bilirubin      205 micro-mol/Lconjugated bilirubin   7 micro-mol/LAST 18 U/L (ref: 12 - 48)ALT  9 U/L  (3 - 55)ALP  77 U/L (30-130)urine bilirubin negativeWhat do you think is the likely cause?Question 9Select one:a.haemolytic anaemiab.obstructive jaundicec.malariad.hepatitis Ae.gallstone

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Solution

The likely cause of Jason's symptoms is haemolytic anaemia. This is because the high level of serum bilirubin and the normal levels of AST, ALT, and ALP suggest that the liver is functioning normally in terms of its ability to process bilirubin. The negative urine bilirubin test also supports this, as it indicates that bilirubin is not being excreted in the urine, which would be expected if there was an obstruction in the bile ducts (as in obstructive jaundice) or liver damage (as in hepatitis A). The normal levels of conjugated bilirubin also suggest that the liver is able to convert unconjugated bilirubin into its conjugated form, which is then normally excreted in the bile. Therefore, the high level of serum bilirubin is likely due to an increased production of bilirubin, which can occur in conditions where there is increased breakdown of red blood cells, such as in haemolytic anaemia.

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