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Which of the following lysosomal storage disease is characterized by loss of myelin and mental retardation*4 pointsTay-Sachs diseaseGaucher's diseaseKrabbe's diseaseAll of these

Question

Which of the following lysosomal storage disease is characterized by loss of myelin and mental retardation*4 pointsTay-Sachs diseaseGaucher's diseaseKrabbe's diseaseAll of these

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Solution

The lysosomal storage disease characterized by loss of myelin and mental retardation is Krabbe's disease.

Here's a brief explanation of each disease:

  1. Tay-Sachs disease: This is a rare and usually fatal genetic disorder that causes progressive damage to the nervous system. However, it is not typically characterized by the loss of myelin.

  2. Gaucher's disease: This is a genetic disorder that affects the body's ability to break down fat that can build up in the liver, spleen, and bone marrow. It does not typically cause loss of myelin or mental retardation.

  3. Krabbe's disease: This is a rare, inherited degenerative disorder of the nervous system, also known as globoid cell leukodystrophy. It is characterized by the loss of myelin (a protective covering of nerve cells) and mental retardation.

So, the correct answer is Krabbe's disease.

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