In atherosclerosis, macrophages attempt (unsuccessfully) to clear the LDL from the tunica intima, resulting in the formation of foam cells within the tunica intima.Group of answer choicesTrueFalse
Question
In atherosclerosis, macrophages attempt (unsuccessfully) to clear the LDL from the tunica intima, resulting in the formation of foam cells within the tunica intima.Group of answer choicesTrueFalse
Solution
True.
In atherosclerosis, macrophages attempt to clear the LDL (low-density lipoprotein) from the tunica intima, the innermost layer of the arterial wall. However, in the case of hyperlipidemia (excess LDL carrying fats and lipids), the amount of LDL in the tunica intima can exceed the capacity of the macrophages to clear it. As a result, the macrophages become overwhelmed and are unable to remove the LDL effectively. This leads to the formation of foam cells within the tunica intima, which are macrophages that have engulfed and become filled with LDL. The accumulation of foam cells within the tunica intima is a hallmark of early atherosclerosis.
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The build up of LDL (containing fat and cholesterol) and foam cells can be seen macroscopically as a fatty streak if you were to open up the blood vessel.Group of answer choicesTrueFalse
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