The alleles of a heterozygous SNP can have different affinities for a transcription factor, resulting in allelic imbalance in transcription factor occupancy (10) and distinct rates of transcription for each allele (19) ( Figure 1c ). Analysis of allele-specific transcription factor binding has played an important role in understanding how noncoding DNA can affect gene expression and contribute to disease phenotypes. In order to fully dissect the implications of altered binding, one should identify the causal gene regulatory variant, the transcription factor that binds to it, and the target gene (20).

The alleles of a heterozygous SNP can have different affinities for a transcription factor,

Heterozygous single-nucleotide polymorphisms (SNPs) in noncoding regions may be causal for ASE by affecting transcription factor binding affinity or causing differences in chromatin state between alternative alleles with a downstream effect on the rate of transcription. Chromatin modifications also play a key role in allelic imbalance of nongenetic origin (including genomic imprinting and X chromosome inactivation). Interplay can also occur between genetic and epigenetic effects through allele-specific DNA methylation

Alleles are described as ______.homologous chromosomesalternate versions of a genealternate phenotypesenvironmental factors that affect gene expression

Any of the alternative versions of a gene that may produce distinguishable phenotypic effects.Group of answer choicesrecessive alleleallelecharactercarrierdominant alleletrait

An individual's allele combination for a particular gene is called the