federally funded research study involving children 8 to 12 years old involves collecting a single voided urine sample to assess the frequency of asymptomatic proteinuria (higher amounts of protein in the urine without any signs or symptoms of illness or infection). Your IRB has determined that assent of children age 8 and older is required for the study. A 10-year-old firmly declined to participate in the study described above. Which of the following procedures best describes the action to be taken by the investigator? Honor the child's decision. Seek permission from one of the child's parent instead. Request the child reconsider assenting to the study. Consent both of the child's parents instead.Question 2A federally funded research study involving children 8 to 12 years old involves collecting a single voided urine sample to assess the frequency of asymptomatic proteinuria (higher amounts of protein in the urine without any signs or symptoms of illness or infection). According to 45 CFR 46, an IRB's risk assessment would likely conclude that this study involves: More than minimal risk with prospect of direct benefit to the child. More than minimal risk with no prospect of direct benefit to the child. No risk to the child and no further IRB review is required. No more than minimal risk to the child.Question 3An investigator proposes a study to determine the clinical relevance of a new assay technique to measure minimal residual disease (MRD) in adolescent (age 14-16) cancer patients undergoing chemotherapy. The study requires that two additional bone marrow aspirates be performed during the course of chemotherapy. The subject's chemotherapy will not be altered based on the results of the assay technique measures. However, future patients with cancer would benefit from improved interventions based on study findings. The IRB determined that the activity was a minor increase over minimal risk. Which of the following statements best describes the IRB approval requirements for involving adolescent cancer patients in the research study? Assent is not required, however, one parent must give permission for the inclusion of the adolescent in this study. Assent is not required, however, both parents must give permission for the inclusion of the adolescent child. Assent of the child only is required. Assent of the child and permission of both parents are required.

Question 1A researcher asks an IRB to waive the requirement for parental permission for a study conducted in schools because the nature of the research requires participation of all the children present in classrooms on the day the research will take place. Assuming that the basic research design could be approved by the IRB and the school, which of the following requirements must be met before an IRB could waive parental permission? The students must be offered an optional classroom activity. Parents must be notified that the study is taking place. An independent consultant must approve the waiver. The research must pose no more than minimal risk.Question 2According to Subpart D, research with children may be eligible for exemption under Category 2 when: The children will be interviewed by the researcher. The children will be asked to complete a survey The research with children will involve participant observation with researcher interaction. The research involves the use of educational testsQuestion 3The specific U.S. Department of Health and Human Services (HHS) regulations that apply to research with children are known as Subpart D: Additional Protections for Children Involved as Subjects in Research. True FalseQuestion 4According to federal regulations, “children” are defined as: Persons who have not yet attained the legal age of consent under the applicable laws in the jurisdiction in which the research was approved. Persons who are under 18 years of age. Persons who have not yet attained the legal age of consent under the applicable laws in the jurisdiction in which the research will be conducted. Persons who are under 21 years of age.Question 5The provisions of Subpart D, of the HHS regulations, Additional Protections for Children Involved as Subjects in Research apply to: All research that is more than minimal risk All research funded by HHS All research involving children All research funded by any federal agency

1-RM testing is contraindicated for children (< 12 years) and older adults (> 60 years).Select one:TrueFalse

When sharing the results of an observation or screening with parents, present a blank sample of the specific tool that was used with their child.TrueFalse

To document that the research participant has voluntarily agreed to participate in the study, the research participant must:A. Pass a test of comprehension.B. Meet with the institution's Institutional Review Board (IRB).C. Sign and date the Informed Consent Form.D. All of the above.

Parents should have access to the screening tool only if it calls for their direct participation.TrueFalse