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When a transdermal drug delivery device is used to administer a drug for systemic absorption, we can detect that the TDDS is actually working by all of the following indicators except which one? A. asking the patient if he thinks it is working B. measurable blood levels of the drug C. detecting the drug or its metabolites in the urine D. observing the clinical response of the patient to the therapeutic effect of the drug

Question

When a transdermal drug delivery device is used to administer a drug for systemic absorption, we can detect that the TDDS is actually working by all of the following indicators except which one?

A. asking the patient if he thinks it is working

B. measurable blood levels of the drug

C. detecting the drug or its metabolites in the urine

D. observing the clinical response of the patient to the therapeutic effect of the drug

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Solution

The correct answer is A. Asking the patient if he thinks it is working. This is not a reliable method to determine if a transdermal drug delivery system (TDDS) is working. The other options (B, C, and D) involve measurable and observable data that can provide concrete evidence of the drug's absorption and effect.

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