1. Metronidazole plasma concentration 6 hours after administration of asingle IV dose of 400mg was 16 mg/L, and the concentration after 10hours was 8.0 mg/L. calculate the elimination rate constan

The elimination rate constant of ibuprofen is 0.1155/hr and its volumeof distribution is 0.17 L/kg. What will be the dosing regimen requiredfor a 70-kg man to achieve an average plasma concentration of 50mg/L at steady state (bioavailability is 100%)a. 100 mg every 8 hoursb. 300 mg every 12 hoursc. 500 mg every 8 hoursd. 400 mg every 6 hours

) An 81 kg cancer patient receives a 6.5 mg/kg IV dose of a chemotherapy drug. Drugplasma levels were monitored over a period of 7.5 hours. At 4.0 hr after doseadministration, the plasma concentration was 69 mg/L, while after 7.2 hr it was 52 mg/L.Note that the drug exhibits first order elimination kinetics.(i) Estimate the elimination rate constant, the volume of distribution, and the half-life of the drug

A 100-mg dose of drug X is given every 8 hr until SS levels are reached. At SS, the AUC over the dosing interval is 32 (mg/L) x hr. What is the average concentration over that dosing interval? What is the estimated clearance for drug X?

Drug A is to be administered at constant rate of 25 mg/hr. The following PK parameters are estimated for this pt: CLs = 15 mL/min, V = 31.5 L, K = 0.029hr. a. Calculate this patient’s plasma concentration at 6 hr and 12 hr after the infusion has begun. b. If the infusion is continued to steady state, what would Css be c. what would be the plasma concentration 24 hr after the infusion is stopped?

for 6hrs the concentration is supposed to be 4.436mg/L, why are u getting 23.8mg/L