what is peak drug x level attained at steady state if 100mg is given intravenous injection every 6hrs. the patient ke=0.35/hr and Vd = 20L

What is the peak drug Z level attained at steady state if 150 mg is given by IV injection every 8 hr, the half-life of drug Z in patient being 6 hr and volume of distribution = 0.3 L/kg? (NB pt wt =75 Kg).

Drug A is to be administered at constant rate of 25 mg/hr. The following PK parameters are estimated for this pt: CLs = 15 mL/min, V = 31.5 L, K = 0.029hr. a. Calculate this patient’s plasma concentration at 6 hr and 12 hr after the infusion has begun. b. If the infusion is continued to steady state, what would Css be c. what would be the plasma concentration 24 hr after the infusion is stopped?

The elimination rate constant of ibuprofen is 0.1155/hr and its volumeof distribution is 0.17 L/kg. What will be the dosing regimen requiredfor a 70-kg man to achieve an average plasma concentration of 50mg/L at steady state (bioavailability is 100%)

A 100-mg dose of drug X is given every 8 hr until SS levels are reached. At SS, the AUC over the dosing interval is 32 (mg/L) x hr. What is the average concentration over that dosing interval? What is the estimated clearance for drug X?

Suppose a patient with severe renal dysfunction receives a 1 gm dose of vancomycin , and the peak concentration , drawn 1 hr after the infusion , is 40 mg/L. A concentration determined 24 hr later is 34 mg/L, but we want to wait till the concentration reaches 10 mg/L before administering a second dose. When will concentration reach 10 mg/L?