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A figure shown below is a transport model for inorganic ions and macromolecules in nuclear porederived from patch-clamp experiments.In the absence of macromolecular transport, the electrical conductance (in pS) of the NPC isvariable, shifting between open and closed states. In the presence of macromolecule transport,the central channel of the NPC is filled with electrically isolating material that plugs the tunnel.This results in a low passive permeability. In the closed state (closed NPC without transportcargo inside) and in the plugged state (open NPC with electrically isolating transport cargoinside), the patch resistance is high (in GΩ). From the patch-clamp recording graph, which of thefollowing would correspond to the “open” state? B

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A figure shown below is a transport model for inorganic ions and macromolecules in nuclear porederived from patch-clamp experiments.In the absence of macromolecular transport, the electrical conductance (in pS) of the NPC isvariable, shifting between open and closed states. In the presence of macromolecule transport,the central channel of the NPC is filled with electrically isolating material that plugs the tunnel.This results in a low passive permeability. In the closed state (closed NPC without transportcargo inside) and in the plugged state (open NPC with electrically isolating transport cargoinside), the patch resistance is high (in GΩ). From the patch-clamp recording graph, which of thefollowing would correspond to the “open” state? B

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