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Which one of the following statements regarding paracetamol overdose is false?Question 4Answera.Kidney injury occurs by metabolite other than NAPQIb.The toxic metabolite in paracetamol overdose is NAPQIc.Patients getting anticonvulsant like phenytoin is high risk of liver injury from paracetamol overdosed.NAC is the antidote to paracetamol overdose

Question

Which one of the following statements regarding paracetamol overdose is false?Question 4Answera.Kidney injury occurs by metabolite other than NAPQIb.The toxic metabolite in paracetamol overdose is NAPQIc.Patients getting anticonvulsant like phenytoin is high risk of liver injury from paracetamol overdosed.NAC is the antidote to paracetamol overdose

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Solution

The statement "Kidney injury occurs by metabolite other than NAPQI" is false. In the case of a paracetamol overdose, the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) is produced in larger amounts than can be detoxified by the liver's glutathione reserves. This excess NAPQI can bind to liver cells, causing damage and potentially leading to liver failure. NAPQI can also cause kidney injury, so it's incorrect to say that kidney injury occurs by a metabolite other than NAPQI.

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N-acetylcysteine (NAC) is often administered for the treatment of acetaminophen overdose to help prevent the toxic metabolite, NAPQI, from accumulating in hepatocytes. This is most likely because NAC:Question 33 Answer Choices   A.  increases the production of NAPQI.   B.  acts as an inhibitor of glutathione reductase.   C.  acts to stimulate the action of CYP1A2.   D.  possesses a, sterically unhindered functional group equivalent to glutathione.

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