Baker-Winegrad Disease is rare congenital disorder caused by a decrease in the activity of fructose-1,6-bisphosphatase. What are the likely symptoms of this disease?Group of answer choicesIncreased glycogen storage and lactate acidosisDecreased glycogen storage and low fasting blood glucose levelsHigh fasting blood glucose levels and lactate acidosisLow fasting blood glucose levels and lactate acidosis
Question
Baker-Winegrad Disease is rare congenital disorder caused by a decrease in the activity of fructose-1,6-bisphosphatase. What are the likely symptoms of this disease?Group of answer choicesIncreased glycogen storage and lactate acidosisDecreased glycogen storage and low fasting blood glucose levelsHigh fasting blood glucose levels and lactate acidosisLow fasting blood glucose levels and lactate acidosis
Solution 1
Baker-Winegrad Disease is likely to cause low fasting blood glucose levels and lactate acidosis. This is because fructose-1,6-bisphosphatase is a key enzyme in gluconeogenesis, the process that produces glucose. A decrease in its activity would lead to lower glucose production, resulting in low blood glucose levels when fasting. The body would then need to rely more on glycolysis for energy, which produces lactate, leading to lactate acidosis.
Solution 2
Baker-Winegrad Disease is likely to cause low fasting blood glucose levels and lactate acidosis. This is because fructose-1,6-bisphosphatase is a key enzyme in gluconeogenesis, the process that produces glucose. A decrease in its activity would lead to lower glucose production, resulting in low blood glucose levels when fasting. The body would then need to rely more on glycolysis for energy, which produces lactate, leading to lactate acidosis.
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