A 45-year-old female is brought to the ED complaining of fatigue. The patient has been feeling extremely weak over the past few days. Today she stood up and almost fainted, prompting her visit. She has had cough, rhinorrhea, and nasal congestion for the past week. Today she also began having nausea, vomiting, and severe abdominal pain. Past medical history is significant for hypertension, CKD, and SLE. Home medications are lisinopril, hydroxychloroquine, and prednisone 20 mg daily. Vitals: Temperature 38.5°C, BP 85/55 mm Hg, HR 126. In general, she appears weak and lethargic. Her heart sounds are tachycardic, regular, without murmurs. Her lungs have occasional rhonchi but no wheezing. Her abdomen is diffusely tender throughout without rebound tenderness. Labs: Na 124 mEq/L, K 5.3 mEq/L, Cr 3.0 mg/dL (baseline 1.8). Hgb is 11.1 g/dL. The patient is diagnosed with Influenza A and started on IV fluids. After 2 L of crystalloid fluids her blood pressure is 90/60 mm Hg. What is the most appropriate next step?Ask StudybuddyGroup of answer choicesMRI pituitaryCT adrenal glandsCortisol levelCosyntropin stimulation testIV hydrocortisone
Question
A 45-year-old female is brought to the ED complaining of fatigue. The patient has been feeling extremely weak over the past few days. Today she stood up and almost fainted, prompting her visit. She has had cough, rhinorrhea, and nasal congestion for the past week. Today she also began having nausea, vomiting, and severe abdominal pain. Past medical history is significant for hypertension, CKD, and SLE. Home medications are lisinopril, hydroxychloroquine, and prednisone 20 mg daily. Vitals: Temperature 38.5°C, BP 85/55 mm Hg, HR 126. In general, she appears weak and lethargic. Her heart sounds are tachycardic, regular, without murmurs. Her lungs have occasional rhonchi but no wheezing. Her abdomen is diffusely tender throughout without rebound tenderness. Labs: Na 124 mEq/L, K 5.3 mEq/L, Cr 3.0 mg/dL (baseline 1.8). Hgb is 11.1 g/dL. The patient is diagnosed with Influenza A and started on IV fluids. After 2 L of crystalloid fluids her blood pressure is 90/60 mm Hg. What is the most appropriate next step?Ask StudybuddyGroup of answer choicesMRI pituitaryCT adrenal glandsCortisol levelCosyntropin stimulation testIV hydrocortisone
Solution
The most appropriate next step in this case would be to administer IV hydrocortisone.
This patient's presentation of hypotension refractory to fluid resuscitation, hyponatremia, hyperkalemia, and fever in the setting of stress (eg, Influenza A infection) is suggestive of adrenal crisis. Adrenal crisis is a life-threatening emergency most commonly precipitated by stress in a patient with chronic adrenal insufficiency.
Chronic adrenal insufficiency (Addison disease) can be due to primary adrenal insufficiency (eg, autoimmune, tuberculosis, metastasis) or secondary adrenal insufficiency (eg, long-term glucocorticoid therapy). This patient's long-term prednisone use for systemic lupus erythematosus likely suppressed the hypothalamic-pituitary-adrenal axis, leading to adrenal atrophy and secondary adrenal insufficiency.
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