The first site for binding tRNA on the ribosome is the A. Peptidyl or donor (P) site B. Aminoacyl or acceptor (A) site C. Exit (E) site
Question
The first site for binding tRNA on the ribosome is the A. Peptidyl or donor (P) site B. Aminoacyl or acceptor (A) site C. Exit (E) site
Solution
The first site for binding tRNA on the ribosome is the Aminoacyl or acceptor (A) site. Here's a step-by-step explanation:
- The process begins when the small ribosomal subunit binds to the mRNA.
- The initiator tRNA, which carries the first amino acid (methionine in eukaryotes or formylmethionine in prokaryotes), binds to the start codon of the mRNA within the P site of the ribosome.
- The large ribosomal subunit then associates with the small subunit.
- The next tRNA (carrying the next amino acid) binds to the A site of the ribosome.
- A peptide bond is formed between the amino acid in the A site and the growing polypeptide chain in the P site.
- The ribosome then translocates, moving the tRNA in the A site to the P site, and the tRNA in the P site to the E site, where it is released. The A site is now free for the next tRNA to bind.
So, while the P site is the first to bind tRNA during initiation, the A site is the first site for tRNA binding during the elongation phase of protein synthesis.
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