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Pain management is not routine in surgery planning of elderly patients. *(-/1 Point)17.

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Pain management is not routine in surgery planning of elderly patients. *(-/1 Point)17.

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Methods OPAL was a triple-blinded, placebo-controlled randomised trial that recruited adults (aged ≥18 years)presenting to one of 157 primary care or emergency department sites in Sydney, NSW, Australia, with 12 weeks or lessof low back or neck pain (or both) of at least moderate pain severity. Participants were randomly assigned (1:1) usingstatistician-generated randomly permuted blocks to guideline-recommended care plus an opioid (oxycodone–naloxone, up to 20 mg oxycodone per day orally) or guideline-recommended care and an identical placebo, for up to6 weeks. The primary outcome was pain severity at 6 weeks measured with the pain severity subscale of the Brief PainInventory (10-point scale), analysed in all eligible participants who provided at least one post-randomisation painscore, by use of a repeated measures linear mixed model. Safety was analysed in all randomly assigned eligibleparticipants. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615000775516).

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