Which of the following statements did Yamanaka rely on for the production of induced pluripotentstem cells (iPSC)? [Note: This is higher level thinking. All statements on their own are correct but youhave to choose the statement that played an essential role in the production of iPSC]?A. All genes retain the potential to be expressed.B. Telomerase is active in stem cells.C. Embryonic stem cells are pluripotent.D. Only a small proportion of genes are expressed in each cel
Question
Which of the following statements did Yamanaka rely on for the production of induced pluripotentstem cells (iPSC)? [Note: This is higher level thinking. All statements on their own are correct but youhave to choose the statement that played an essential role in the production of iPSC]?A. All genes retain the potential to be expressed.B. Telomerase is active in stem cells.C. Embryonic stem cells are pluripotent.D. Only a small proportion of genes are expressed in each cel
Solution
The statement that Yamanaka relied on for the production of induced pluripotent stem cells (iPSC) is:
A. All genes retain the potential to be expressed.
This is because Yamanaka's work was based on the idea that mature cells could be reprogrammed to become pluripotent by introducing genes that are normally active in embryonic stem cells. This concept relies on the understanding that all genes in a cell, regardless of the cell's type or maturity, retain the potential to be expressed under the right conditions.
The other options, while correct, are not the fundamental principles that Yamanaka's iPSC production relied on.
B. Telomerase is active in stem cells - This is true, but it is not the key principle for iPSC production. Telomerase activity helps with the longevity and 'immortality' of stem cells, but it is not directly related to the pluripotency that characterizes iPSCs.
C. Embryonic stem cells are pluripotent - This is also true, but it is not the principle that Yamanaka's method relies on. Rather, it is the goal of the method to induce this state in mature cells.
D. Only a small proportion of genes are expressed in each cell - While this is a general truth about gene expression, it is not the key to Yamanaka's method. His method relies on the potential for any gene to be expressed, not the proportion of genes that are actually expressed in a given cell at a given time.
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