However, numerous groups including ours have reported that neutralising titres in convalescent subjects are comparatively weak11,12,14,15,17 and appear to wane rapidly36,37,38. Here a simple two protein regime using licensure-friendly adjuvants was able to elicit superior binding and neutralising antibody responses. Prototypic vaccines induced strong GC activity in draining lymph nodes, driving maturation of S-specific B cells, and seeded memory T and B-cell responses in the blood. Overall, our study suggests that vaccination constitutes a more robust and reliable pathway to serological protection against SARS-CoV-2 than natural infection, similar to other pathogens such as human papillomavirus39,40.
Question
However, numerous groups including ours have reported that neutralising titres in convalescent subjects are comparatively weak11,12,14,15,17 and appear to wane rapidly36,37,38. Here a simple two protein regime using licensure-friendly adjuvants was able to elicit superior binding and neutralising antibody responses. Prototypic vaccines induced strong GC activity in draining lymph nodes, driving maturation of S-specific B cells, and seeded memory T and B-cell responses in the blood. Overall, our study suggests that vaccination constitutes a more robust and reliable pathway to serological protection against SARS-CoV-2 than natural infection, similar to other pathogens such as human papillomavirus39,40.
Solution
This passage discusses the efficacy of a two-protein vaccine regimen in eliciting a stronger immune response against SARS-CoV-2 than natural infection. The vaccine was found to stimulate strong germinal center (GC) activity in draining lymph nodes, which promotes the maturation of S-specific B cells. It also induced memory T and B-cell responses in the blood. The authors conclude that vaccination is a more robust and reliable method of achieving serological protection against SARS-CoV-2 than natural infection, drawing parallels with other pathogens such as the human papillomavirus.
Similar Questions
Vaccination typically involves at least two injections about 6 weeks apart. This drives which important process in adaptive immunity?Select one alternative:B cell replicationgene rearrangementT cell replicationaffinity maturation
Vaccines require the adaptive immune system to be stimulated to generate long-lasting immunity. Name one type of antigen-presenting cell responsible for initiating the adaptive immune response.
The formation of memory immune responses is the objective of vaccination. Immunological memory is predominantly the function of which of the following?
This particular vaccine is important because the natural infection doesnot confer lifelong immunity:
Select all major characteristics of B cells.Multiple select question.Mature in the thymusProduces memory cells with clonal expansionRecognize antigens presented by MHC moleculesCarry out antibody-mediated immunity
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