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Which of the follow statements on EBV is NOT correct?Group of answer choicesThe mechanism by which EBV virions enter B cells is similar to how HSV virions enter cells, in that the viral envelope fuses to the plasma membrane.In EBV latent infections, viral miRNAs and stable noncoding RNAs called EBERs are produced.LMP1 is in the plasma membrane of latency II and latency III cells, where it helps to protect the cell from apoptosis.EBNA1 binds oriP to initiate DNA replication from the oriP DS element.EBNA1 promotes cell survival by lowering the levels of p53 and PML proteins.

Question

Which of the follow statements on EBV is NOT correct?Group of answer choicesThe mechanism by which EBV virions enter B cells is similar to how HSV virions enter cells, in that the viral envelope fuses to the plasma membrane.In EBV latent infections, viral miRNAs and stable noncoding RNAs called EBERs are produced.LMP1 is in the plasma membrane of latency II and latency III cells, where it helps to protect the cell from apoptosis.EBNA1 binds oriP to initiate DNA replication from the oriP DS element.EBNA1 promotes cell survival by lowering the levels of p53 and PML proteins.

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Solution

The statement that is NOT correct about Epstein-Barr Virus (EBV) is: "EBNA1 promotes cell survival by lowering the levels of p53 and PML proteins."

EBNA1 (Epstein-Barr Nuclear Antigen 1) is indeed a protein expressed in all types of EBV latency and is essential for the replication and partitioning of the EBV genome during latency. However, it does not promote cell survival by lowering the levels of p53 and PML proteins. Instead, EBNA1 has been shown to enhance cell survival by upregulating cellular anti-apoptotic proteins and downregulating pro-apoptotic proteins. It also inhibits the cellular DNA damage response, but it does not directly lower the levels of p53 and PML proteins.

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Similar Questions

Which of the follow statements on Epstein-Barr virus (EBV) is NOT correct?Group of answer choicesEBV virions are produced in the oral epithelium and spread in saliva.Most B lymphocytes in your blood are latently infected with EBV.EBV can induce B cell lymphomas after organ transplant because the patient is immunocompromised and therefore their immune system does not kill the latency III cells.Persistent EBV infection can lead to gastric carcinoma and multiple sclerosis.Expression of BZLF1 causes a switch from latent to lytic EBV infection in the same cell.

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