When synthesizing MHC II peptides for presentation, an APC can combine ________.1 pointa maternal DQ α with a paternal DQβa maternal DQ α with a maternal DQαa maternal DQ α with a maternal DPβA and BA and CB and C
Question
When synthesizing MHC II peptides for presentation, an APC can combine ________.1 pointa maternal DQ α with a paternal DQβa maternal DQ α with a maternal DQαa maternal DQ α with a maternal DPβA and BA and CB and C
Solution
The correct answer is "a maternal DQ α with a paternal DQβ".
This is because MHC II molecules are heterodimers, meaning they are composed of two different protein subunits. In humans, these subunits are encoded by the HLA-DQ and HLA-DP genes. Each person inherits one set of these genes from each parent, so they have both maternal and paternal versions.
During the process of antigen presentation, an antigen presenting cell (APC) can combine a DQ α chain from the mother with a DQ β chain from the father to form a functional MHC II molecule. This molecule can then bind to a peptide antigen and present it to a T cell, triggering an immune response.
The other options are not correct because they involve combining two α chains or two β chains, which would not result in a functional MHC II molecule. Also, the options "A and B" and "B and C" do not make sense in this context, as they do not specify any particular combinations of MHC II subunits.
Similar Questions
Describe the process of antigen processing and presentation with MHC I and MHC II
Compared to the MHC molecule on the left, the MHC molecule on the right (in the drawing above) will bind a ______ peptide that, if foreign, will cause a T cell to activate and _________. The protein on the left is made up of two peptides, each with two domains. One peptide has domains labeled alpha 1 and 2, the other beta 1 and 2. The protein on the right is made up of two peptides, one with three domains labeled alpha 1, 2 and 3 and the other a single domain labeled beta MG.
An APC bearing MHC-antigen complexes on its cell surface migrates to lymphoid tissues and interacts with which of the following cells?ANSWERB cells and T helper cellsT helper cells and T cytotoxic cellsT cytotoxic cells onlyT helper cells only
There is no gene for ______ located in the MHC locus.1 pointcytokinesproteins that form part of the MHC I presenting moleculeenzymes that transport peptides into the ERproteins that determine the length of peptides hydrolyzed in the proteasomeproteins that associate with CD4
CD4 attaches to the base of MHC _______ and stabilizes the binding of antigen to the αβ receptors of ________ cells.1 pointI; TCI; THII; TCII; TH
Upgrade your grade with Knowee
Get personalized homework help. Review tough concepts in more detail, or go deeper into your topic by exploring other relevant questions.