Which of the following peptide sequences would best fulfil the role of one of the transmembrane helices lining the glucose transport channel of GLUT1? Group of answer choices KLVTEFIDLVRILVRLVDIVL TLVSNFITLVSNLVTLVSIVL VSTLSNTVSTLSNTLSSITSN VRELKREVRKLERKIEEVKRK
Question
Which of the following peptide sequences would best fulfil the role of one of the transmembrane helices lining the glucose transport channel of GLUT1? Group of answer choices
KLVTEFIDLVRILVRLVDIVL
TLVSNFITLVSNLVTLVSIVL
VSTLSNTVSTLSNTLSSITSN
VRELKREVRKLERKIEEVKRK
Solution
The peptide sequence that would best fulfil the role of one of the transmembrane helices lining the glucose transport channel of GLUT1 is TLVSNFITLVSNLVTLVSIVL.
Step by Step Explanation:
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GLUT1 is a glucose transporter that facilitates the transport of glucose across the plasma membranes of mammalian cells. It is a transmembrane protein, meaning it spans the entire lipid bilayer.
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Transmembrane proteins often have alpha-helices that span the membrane. These helices are typically composed of hydrophobic (water-repelling) amino acids, as they interact with the hydrophobic core of the lipid bilayer.
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Looking at the given peptide sequences, we need to find a sequence that is primarily composed of hydrophobic amino acids.
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The sequence TLVSNFITLVSNLVTLVSIVL is composed mostly of hydrophobic amino acids (Threonine (T), Leucine (L), Valine (V), Isoleucine (I), Phenylalanine (F)), making it a good candidate for a transmembrane helix.
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Therefore, the correct answer is TLVSNFITLVSNLVTLVSIVL.
The other sequences contain multiple charged or polar amino acids (K, E, R, S), which would not be favorable in the hydrophobic environment of the lipid bilayer.
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