Put the steps involved in muscle contraction in the correct chronological order after an action potential arrives at the motor neuron axon terminal:
Question
Put the steps involved in muscle contraction in the correct chronological order after an action potential arrives at the motor neuron axon terminal:
Solution
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The action potential arrives at the axon terminal of the motor neuron.
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This triggers the opening of voltage-gated calcium channels, allowing calcium ions to enter the neuron.
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The influx of calcium ions causes synaptic vesicles to fuse with the membrane and release the neurotransmitter acetylcholine into the synaptic cleft.
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Acetylcholine diffuses across the synaptic cleft and binds to receptors on the sarcolemma (muscle cell membrane).
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This binding opens ion channels, allowing sodium ions to enter the muscle cell and potassium ions to exit. This change in ion concentration causes a depolarization that is conducted down the T-tubules.
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The depolarization triggers the release of calcium ions from the sarcoplasmic reticulum into the sarcoplasm (muscle cell cytoplasm).
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The calcium ions bind to troponin, causing a conformational change that moves tropomyosin away from the myosin-binding sites on actin filaments.
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Myosin heads bind to the exposed sites on the actin, forming cross-bridges.
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The myosin heads pivot, pulling the actin filaments toward the center of the sarcomere. This is the power stroke that causes muscle contraction.
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ATP binds to the myosin heads, causing them to detach from the actin. The ATP is then hydrolyzed, re-energizing the myosin heads and allowing them to bind to actin again for another power stroke.
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The process of cross-bridge formation, power stroke, and cross-bridge detachment repeats as long as calcium ions and ATP are available.
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When the action potential ends, calcium ions are pumped back into the sarcoplasmic reticulum, tropomyosin covers the myosin-binding sites on actin again, and the muscle relaxes.
Similar Questions
medical student was doing research in a laboratory that studiesthe neuromuscular junction. Which of the following events atthe junction are listed in correct sequential order?A. Motor neuron action potential, acetylcholine release, Na+entry at the endplateB. Ca2+ entry into the motor nerve terminal, Na+ entry at theendplate, muscle fiber action potentialC. Na+ entry at the endplate, acetylcholine release, muscle fiberaction potentialD. Motor neuron action potential, Na+ entry at the endplate,formation of an endplate potentialE. Ca2+ entry into the motor nerve terminal, acetylcholinerelease, Na+ entry at the endplate
Place the steps of the muscle action potential in the appropriate order.Rank the options below.An action potential arrives at the presynaptic terminal.An action potential arrives at the presynaptic terminal. open choices for rankingCalcium ions enter the presynaptic terminal.Calcium ions enter the presynaptic terminal. open choices for rankingACh binds to and opens ligand-gated Na+ channels on the postsynaptic membrane.ACh binds to and opens ligand-gated Na+ channels on the postsynaptic membrane. open choices for rankingVoltage-gated Ca2+ channels in the presynaptic membrane open.Voltage-gated Ca2+ channels in the presynaptic membrane open. open choices for rankingNa+ enters the postsynaptic cell.Na+ enters the postsynaptic cell. open choices for rankingThe enzyme acetylcholinesterase removes acetylcholine from the synaptic cleft.The enzyme acetylcholinesterase removes acetylcholine from the synaptic cleft. open choices for rankingThe neurotransmitter acetylcholine (ACh) is released from pre-synaptic vesicles.The neurotransmitter acetylcholine (ACh) is released from pre-synaptic vesicles. open choices for rankingACh unbinds from the ligand-gated Na+ channels, which then close.ACh unbinds from the ligand-gated Na+ channels, which then close. open choices for rankingPostsynaptic membrane begins to depolarize.Postsynaptic membrane begins to depolarize. open choices for rankingACh is released and diffuses into the synaptic cleft.ACh is released and diffuses into the synaptic cleft. open choices for rankingIf depolarization passes threshold, an action potential is generated along the postsynaptic membrane.If depolarization passes threshold, an action potential is generated along the postsynaptic membrane. open choices for ranking
The sequence of events that converts action potentials in a muscle fibre to a contraction is known as
n regards to excitation-contraction coupling, what does the action potential propagate along when it reaches the muscle?
Arrange these action potential events in their proper sequence: (1) The neuron is stimulated at the dendrites (2) K+ gates open (3) The neuron is in a polarized “resting” state (4) Na+ gates open (5) The cell is fully depolarized (6) The cell is fully repolarized a. 1, 2, 4, 3, 5, 6b. 3, 1, 4, 5, 2, 6c. 4, 6, 2, 1, 5, 3d. 1, 4, 2, 6, 5, 3
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