Consider the process of loading of antigen on MHC I. Beginning with the synthesis of MHC I in the RER, order the following events, finishing with the MHC I-antigen complex extending outward from the cell.I. association with β microglobulinII. loading of antigenIII. travel through the GolgiIV. association with tapasinV. binding of calnexin

1.抗原呈獻細胞的胞內體（endosome）中，下列何種分子會先占據MHC class II的胜肽結合位，之後HLA-DM再媒介細胞外抗原與此分子交換結合位？單選題(1 分) A.TAP（transporter associated with antigen processing） B.Calreticulin C.CLIP（class II-associated invariant chain peptide） D.HLA-DO2.下列有關CD4 T細胞常見功能之敘述，何者錯誤？單選題(1 分) A.可活化巨噬細胞，增進其消滅病原菌的能力 B.可幫助B細胞分泌更高親和力的抗體 C.可直接殺死病毒感染的細胞 D.可活化嗜酸性球，使其能消滅寄生蟲3.下列有關一般的CD8 T細胞之敘述，何者錯誤？單選題(1 分) A.辨識由抗原呈獻細胞上MHC class II呈獻之抗原片段 B.可直接毒殺被病毒感染的細胞 C.IL-2可促其增生 D.第一型干擾素可促其增生4.下列有關NK細胞的敘述，何者錯誤？單選題(1 分) A.表現TLR-3（toll-like receptor 3） B.僅表現活化型（activating）受體 C.病毒感染時，比T細胞作用早 D.可以辨識 altered MHC class I分子5.下列有關B細胞作為抗原呈獻細胞時的特性，何者錯誤？單選題(1 分) A.B細胞表面穩定表現MHC class II B.B細胞表面穩定表現高量的CD80和CD86 C.比樹突細胞不易活化naive T細胞 D.B細胞以表面免疫球蛋白結合抗原，進行胞吞6.下列有關Th17細胞之敘述，何者錯誤？單選題(1 分) A.可分泌IL-22 B.主要表現轉錄因子GATA3 C.可由TGF-β和IL-6誘導分化 D.有助於細胞外病原菌的清除7.下列有關B細胞受體（BCR）複合體相關的訊息傳遞，何者錯誤？單選題(1 分) A.CD21/19/81是BCR複合體之輔助受體 B.Syk激酶能與BCR複合體 Igβ已磷酸化的酪胺酸基結合 C.ZAP-70激酶能與BCR複合體 Igα已磷酸化的酪胺酸基結合 D.CD40是BCR複合體之輔助受體8.下列有關膠原凝集素（collectins）之敘述，何者正確？單選題(1 分) A.Surfactant protein A、surfactant protein D及ficolins均屬於其家族之成員 B.其單體結構之N-terminus為C-type lectin區域，C-terminus則為類似膠原蛋白（collagen-like）之區域 C.屬於先天性免疫之成員，且為模式識別受體 PRRs（pattern recognition receptors） D.其結構通常為多聚體，例如mannose-binding lectin結構主要為二聚體或五聚體9.下列有關慢性肉芽腫疾病（chronic granulomatous disease, CGD）之敘述，何者正確？單選題(1 分) A.病人的吞噬細胞無法吞噬病原體也無法殺死病原體 B.慢性肉芽腫疾病的發生，常見為cytochrome b558之突變 C.體染色體隱性遺傳CGD主要是因為NADPH oxidase complex中gp91 subunit缺失所造成 D.X性染色體遺傳CGD主要是因為NADPH oxidase complex中p47 phox subunit缺失所造成

Describe the process of antigen processing and presentation with MHC I and MHC II

Compared to the MHC molecule on the left, the MHC molecule on the right (in the drawing above) will bind a ______ peptide that, if foreign, will cause a T cell to activate and _________. The protein on the left is made up of two peptides, each with two domains. One peptide has domains labeled alpha 1 and 2, the other beta 1 and 2. The protein on the right is made up of two peptides, one with three domains labeled alpha 1, 2 and 3 and the other a single domain labeled beta MG.

The β microglobulin molecule has the most significant sequence homology to the _____ domain of MHC II. However, unlike this domain, it does not have a (n) _______.1 pointβ1; antigen binding siteβ1; membrane-spanning domainβ2; antigen binding siteβ2; membrane-spanning domain

Which series shows the order by which an antigenic sequence of amino acids is brought in contact with a T-cell receptor by a major histocompatibility complex (MHC)?A.Full-length protein → MHC I → MHC II → T-cell receptorB.Full-length protein → MHC II → MHC I → T-cell receptorC.Full-length protein → free digested protein fragments → MHC II → T-cell receptorD.Full-length protein → free digested protein fragments → MHC I → free digested protein fragments → T-cell receptorSubmit