Amides are most efficiently prepared from which of the following?Select answer from the options belowCarboxylic acidsEstersAcid chloridesSave for LaterSubmit Answer
Question
Amides are most efficiently prepared from which of the following?Select answer from the options belowCarboxylic acidsEstersAcid chloridesSave for LaterSubmit Answer
Solution
Amides are most efficiently prepared from Acid chlorides.
Here's a step-by-step explanation:
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Acid chlorides are highly reactive due to the good leaving group (Cl-).
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When amines, which are nucleophiles, react with acid chlorides, they attack the carbonyl carbon, causing the pi electrons to move up to the oxygen.
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The electrons then come back down to reform the carbonyl and kick out the chloride as a leaving group.
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This results in the formation of an amide.
So, Acid chlorides are the most efficient precursors for the preparation of amides.
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