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he enzymes involved in ubiquitinylation of cell-cycle proteins are(A) E1 and E2 only(B) E1 and E3 only(C) E1 and E4 only(D) E1, E2 and E

Question

he enzymes involved in ubiquitinylation of cell-cycle proteins are(A) E1 and E2 only(B) E1 and E3 only(C) E1 and E4 only(D) E1, E2 and E

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Solution

The process of ubiquitination involves three main types of enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). These enzymes work together in a cascade to attach ubiquitin to target proteins, which can then be recognized and degraded by the proteasome. Therefore, the correct answer is (D) E1, E2, and E3.

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The role of ubiquitin in cell cycle control is to:Group of answer choicesstimulate cyclin synthesisdephosphorylate cyclindegrade cyclinphosphorylate cyclin

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The process of ubiquitination largely in part serves the purpose ofGroup of answer choicesacting as a protein marker for degradationdetermining protein localization inside cellscovalent modificationa and cnone of the above

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What role does the proteasome play in the regulation of the cell cycle?Group of answer choicesIt degrades ubiquitinated cyclin as part of a positive CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated cyclin as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a positive CDK/cyclin feedback mechanism.

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