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Scientists could confirm that an allosteric effector increases the catalytic efficiency of an enzyme if it has what effect on kcat and Km?A.kcat decreases, Km increasesB.kcat decreases, Km remains unchangedC.kcat increases, Km decreasesD.kcat remains unchanged, Km increases

Question

Scientists could confirm that an allosteric effector increases the catalytic efficiency of an enzyme if it has what effect on kcat and Km?A.kcat decreases, Km increasesB.kcat decreases, Km remains unchangedC.kcat increases, Km decreasesD.kcat remains unchanged, Km increases

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Solution

The catalytic efficiency of an enzyme is determined by the ratio of kcat/Km. An increase in catalytic efficiency would therefore require an increase in kcat, the turnover number (which measures how many substrate molecules one enzyme molecule can convert per second), and/or a decrease in Km, the Michaelis constant (which measures the concentration of substrate at which the reaction rate is half its maximum).

So, an allosteric effector that increases the catalytic efficiency of an enzyme would have the effect of increasing kcat and decreasing Km. Therefore, the correct answer is C. kcat increases, Km decreases.

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