Which word list best fill the gaps in the following paragraph? (note we didn’t cover the exact details in lectures, but you can work this out). The common brushtail possum (Trichosurus vulpecula), is a noxious pest in Aotearoa/New Zealand and is poisoned with sodium fluoroacetate (1080). This poison inhibits the citric acid cycle (CAC). Poisoned animals accumulate large amounts of citrate and oxaloacetate. The mode of action of this poison is that sodium fluoroacetate mimics (a) __________ and instead of forming acetyl-CoA it forms fluoroacetyl-CoA. The enzyme (b)__________ __________ then binds (c) __________, which then forms fluorocitrate. This then binds to and inhibits the enzyme (d) _________.Select one alternative:(a) lactate, (b) aconitase, (c) malate, (d) citrate synthase(a) glucose, (b) wishIknewthisase, (c) ATP, (d) PFK(a) acetate, (b) citrate synthase, (c) oxaloacetate, (d) aconitase(a) acetate, (b) succinate dehydrogenase, (c) fumarate, (d) aconitase
Question
Which word list best fill the gaps in the following paragraph? (note we didn’t cover the exact details in lectures, but you can work this out). The common brushtail possum (Trichosurus vulpecula), is a noxious pest in Aotearoa/New Zealand and is poisoned with sodium fluoroacetate (1080). This poison inhibits the citric acid cycle (CAC). Poisoned animals accumulate large amounts of citrate and oxaloacetate. The mode of action of this poison is that sodium fluoroacetate mimics (a) and instead of forming acetyl-CoA it forms fluoroacetyl-CoA. The enzyme (b)______ __________ then binds (c) __________, which then forms fluorocitrate. This then binds to and inhibits the enzyme (d) _________.Select one alternative:(a) lactate, (b) aconitase, (c) malate, (d) citrate synthase(a) glucose, (b) wishIknewthisase, (c) ATP, (d) PFK(a) acetate, (b) citrate synthase, (c) oxaloacetate, (d) aconitase(a) acetate, (b) succinate dehydrogenase, (c) fumarate, (d) aconitase
Solution
The correct alternative is:
(a) acetate, (b) citrate synthase, (c) oxaloacetate, (d) aconitase
Here's why:
(a) Sodium fluoroacetate mimics acetate. Acetate is the ionized form of acetic acid, which is a part of the citric acid cycle. It is converted into acetyl-CoA, which is a key molecule in the cycle.
(b) Citrate synthase is the enzyme that binds with oxaloacetate. This enzyme catalyzes the condensation of oxaloacetate with acetyl CoA to form citrate, which is the first step of the citric acid cycle.
(c) Oxaloacetate is the molecule that citrate synthase binds with. It is a four-carbon molecule that combines with acetyl CoA to form citrate in the citric acid cycle.
(d) Aconitase is the enzyme that is inhibited by fluorocitrate. Aconitase is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process.
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