Original mRNA: 5’ UUU-AAA-GCC-UAC 3’Which of the following results in a frameshift mutation? [B.2G]Select one:a.5’ UUU-AAA-GCC-UAU 3’b.5’ UUU-AAA-GCC-UAA 3’c.5’ UAU-UAA-AGC-CUA-C 3’d.5’ UUU-AAA-GCG-UAC 3’
Question
Original mRNA: 5’ UUU-AAA-GCC-UAC 3’Which of the following results in a frameshift mutation? [B.2G]Select one:a.5’ UUU-AAA-GCC-UAU 3’b.5’ UUU-AAA-GCC-UAA 3’c.5’ UAU-UAA-AGC-CUA-C 3’d.5’ UUU-AAA-GCG-UAC 3’
Solution
The answer is c. 5’ UAU-UAA-AGC-CUA-C 3’. A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. In this case, an extra base (U) is added at the beginning of the sequence, shifting the reading frame of the entire sequence.
Similar Questions
In a frameshift mutation, all of the amino acids before the shift are changed.Multiple ChoiceFalseTrue
The addition of a single nucleotide to the DNA sequence causes a frameshift mutation.Multiple ChoiceTrueFalse
Which of the following describes a frameshift mutation?Insertion or deletion of a group of three nucleotides within a reading frameInsertion or deletion of nucleotides that results in a premature stop codonInsertion or deletion of a group of three nucleotides outside a reading frameSubstitution of one nucleotide for another
Which of the following mRNA strands contains the longest open reading frame?A.5′-CCACGAUGCGUUGAGCGC-3′B.5′-CAAUGGUAAAGUCUUAGU-3′C.5′-GACGAUGUAACUUGCACU-3′D.5′-AGAAUGGUAUCCUGAGCC-3′
Here is an mRNA from a different gene (it is the middle of the sequence, so it has no AUG). Questions 2- 6 relate to this gene. 5’ GUA UGG GAU CGC AAU 3’
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