A medical student is studying neurons that are part of adescending pain modulating pathway. What brain region iscorrectly paired with the neurotransmitters it releases and thelocation where the neurotransmitter is released?A. Periaqueductal gray neurons release endorphins in thespinal dorsal horn.B. Nucleus raphe magnus releases serotonin in the dorsal rootganglion.C. Locus coeruleus neurons release serotonin in the nucleusraphe magnus.D. Locus coeruleus neurons release norepinephrine in thespinal dorsal horn.E. Periaqueductal gray releases dynorphin in the rostralventromedial medulla
Question
A medical student is studying neurons that are part of adescending pain modulating pathway. What brain region iscorrectly paired with the neurotransmitters it releases and thelocation where the neurotransmitter is released?A. Periaqueductal gray neurons release endorphins in thespinal dorsal horn.B. Nucleus raphe magnus releases serotonin in the dorsal rootganglion.C. Locus coeruleus neurons release serotonin in the nucleusraphe magnus.D. Locus coeruleus neurons release norepinephrine in thespinal dorsal horn.E. Periaqueductal gray releases dynorphin in the rostralventromedial medulla
Solution
The correct answer is A. Periaqueductal gray neurons release endorphins in the spinal dorsal horn.
Here's why:
The Periaqueductal gray (PAG) is a brain region that plays a crucial role in pain modulation. It is part of a descending pain modulating pathway that can inhibit pain signals in the spinal cord before they reach the brain. The PAG does this by releasing endorphins, which are natural painkillers, into the spinal dorsal horn.
The other options are incorrect because:
B. The Nucleus raphe magnus releases serotonin, but it does so in the spinal cord, not the dorsal root ganglion.
C. The Locus coeruleus does release serotonin, but it does so in the spinal cord, not the nucleus raphe magnus.
D. The Locus coeruleus does release norepinephrine, but it does so in the brain, not the spinal dorsal horn.
E. The Periaqueductal gray does release dynorphin, but it does so in the spinal cord, not the rostral ventromedial medulla.
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