Le bcr (b-cell receptor) reconnaitALes déterminants antigéniques séquentielsBLes déterminants antigéniques conformationnelsCLes antigènes seulsDLes antigènes en association à une molécule du cmhELes antigènes à l'état natif

Which of the following statements about the generation of B cell receptor (BCR) diversity is FALSE?Select one alternative:Rearrangement of the gene segments coding the variable region of light and heavy chains is the only process by which BCR diversity is generated.Animals have multiple copies of the gene segments that code for the variable region of the heavy and light chains.Rearrangement of the gene segments that code for the variable region of light and heavy chains is a random process.The variable region of the heavy chain is coded by the V, D and J gene segments.

La molécule cd3AFait partie du récepteur de cellules t (tcr)BFait partie du b-cell receptor (bcr)CEst un marqueur de lignéeDEst un marqueur d’activationEEst retrouvée sur les thymocytes au 1er stade de maturation

Which of the following does not describe B-cell receptors?Group of answer choicesB-cell receptors are membrane-bound and secretedB-cell receptors consist of a variable region and a constant regionB-cell receptors lack specificity and can bind to a number of different antigensB-cell receptors possess specificity and can therefore bind only to unique epitopes

Select all major characteristics of B cells.Multiple select question.Mature in the thymusProduces memory cells with clonal expansionRecognize antigens presented by MHC moleculesCarry out antibody-mediated immunity

T cell maturation and development of their antigen-specific receptors takes place in the . B cells mature in the where they also develop their specificity to a single antigen. This specificity in both B and T cells is made possible through genetic . The genes that code for the variable regions of both B and T cell receptors are cut and spliced during the process of both cells. Because genetic rearrangement occurs at the level of the rather than in the RNA following , the changes are permanent, resulting in each cell being capable of binding to a single antigen in a pool of up to 1018 possible variations. B cell receptors are that are comprised of four and have two identical antigen binding sites. The region of the immunoglobulin is embedded in the cell membrane, and the variable regions are facing outward in order to bind to their potential antigenic match. Unlike B cell receptors, T cell receptors are comprised of two polypeptides and have antigen binding site(s) that is exposed. Like B cell receptors, their specificity to a single antigen is determined any encounters with antigens.