Duringaffinity maturation, B-cells will undergo somatic hypermutation in the ______zone and selection for improved CDR binding in the _______ zone. After theseprocesses the TH cell may direct the B cell to leave and head to thesite of an infection and secrete antibodies there, which will cause the B cellto _________.

T and B cells undergo the development and maturation process in ______.

After arrival of antigen in lymphoid tissue and the activation of resident B cells, which of the following processes does NOT occur in the lymphoid follicles?Select one alternative:Isotype switching of B cells to change the Fc region of the antibody that will be produced.Affinity maturation of the B cells to produce antibody of the highest affinity for the antigen.Migration of B cells into T cell rich areas of the follicle to receive T cell help.Clonal proliferation to produce an "army" of identical B cells with the same antigen-binding specificity.

A naïve B cell recognises and binds to a polysaccharide from S.aureus. What is likely to happen next?Group of answer choicesThe B cell will enter into the germinal centre reactionThe B cell will differentiate to a short-lived plasma cellThe B cell begin to express CD40L on the cell surfaceThe B cell will phagocytose the polysaccharide and present it on MHC-II to a T follicular helper cell

B lymphocytes that have been exposed to an antigen develop into cells that produce antibodies called _____ cells.Group of answer choicesplasmamemorybursaKupffer

Whichof the following processes in the differentiation of the B-cell lineage takesplace primarily in the bone marrow (as opposed to the lymph nodes)?1 point removalof the gene regions coding for the mand δ heavy chain constant domains mutationdirected to the variable domain regions specifying the structures of the CDRloops negativeselection to remove B cells that recognize self-antigen activationof B cells by foreign antigen rearrangementof the genes that code for T-cell receptors