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Match the immune tolerance mechanisms in Group I with their respectiveoutcomes in Group II.Group I Group IIP. Anergy 1. Elimination of activated T-cellsafter antigen clearanceQ. Activation-induced cell death 2. Inhibition of auto-reactive T-cells atperipheryR. Receptor editing 3. Unresponsiveness to antigens due tolack of co-stimulatory moleculesS. Regulatory T-cells 4. Elimination of auto-reactive B-cells(A) P-3, Q-1, R-4, S-2(B) P-4, Q-3, R-1, S-2(C) P-3, Q-4, R-2, S-1(D) P-3, Q-2, R-4, S-1

Question

Match the immune tolerance mechanisms in Group I with their respectiveoutcomes in Group II.Group I Group IIP. Anergy 1. Elimination of activated T-cellsafter antigen clearanceQ. Activation-induced cell death 2. Inhibition of auto-reactive T-cells atperipheryR. Receptor editing 3. Unresponsiveness to antigens due tolack of co-stimulatory moleculesS. Regulatory T-cells 4. Elimination of auto-reactive B-cells(A) P-3, Q-1, R-4, S-2(B) P-4, Q-3, R-1, S-2(C) P-3, Q-4, R-2, S-1(D) P-3, Q-2, R-4, S-1

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Solution

The correct answer is (A) P-3, Q-1, R-4, S-2.

Here's why:

P. Anergy is a state of unresponsiveness to antigens due to lack of co-stimulatory molecules, so it matches with 3.

Q. Activation-induced cell death refers to the elimination of activated T-cells after antigen clearance, so it matches with 1.

R. Receptor editing is a process that leads to the elimination of auto-reactive B-cells, so it matches with 4.

S. Regulatory T-cells play a role in the inhibition of auto-reactive T-cells at the periphery, so it matches with 2.

This problem has been solved

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