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The main factor responsible for extrinsic pathway of apoptosis is:Select one:a. TNFb. Cytochrome cc. BCl2d. Caspases

Question

The main factor responsible for extrinsic pathway of apoptosis is:Select one:a. TNFb. Cytochrome cc. BCl2d. Caspases

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Solution

The main factor responsible for the extrinsic pathway of apoptosis is:

a. TNF

The extrinsic pathway of apoptosis is triggered by external signals, such as the binding of death ligands (like TNF, Fas ligand) to their respective death receptors on the cell surface. This leads to the activation of caspases (like caspase 8 and 10), which are the main executioners of apoptosis. However, the initial trigger in this pathway is the binding of a death ligand to its receptor, so the correct answer is a. TNF.

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