A 52-year-old woman who has been diagnosed with bipolar disorder needs a refill on her lithium prescrip- tion. She also has hypertension that is well controlled with an ACE inhibitor. Lithium has a narrow thera- peutic index. Which of the following describes a nar- row therapeutic index? * (A) The chance of toxicity is remote at the therapeu- tic dose (B) The ratio of TD50 to ED50 equals 1 (C) The ratio of TD50 to ED50 is less than 1 (D) The therapeutic dose approaches the toxic dose (E) The therapeutic dose is much greater than the toxic dose

E.l is a 35-year-old 65kg white male being treated for acute mania. he is receiving 300mg lithium carbonate 3 time daily. His serum creatinine concentration is 0.9mg/dl. Calculate the expected lithium concentration just before the morning dose on the forth day of therapy. Some parameters of lithium Bioavailability=100% Clearance of lithium=25% of creatinine clearance Vd=0.7L/kg Molecular weight of lithium= 73.9g/mol

A nursing student is reinforcing education to a client diagnosed with bipolar disorder about lithium therapy. Which of the following statements by the student requires further intervention by the nurse?Cassidy RhodyID: 112703Question 7Select one:a.Lithium toxicity can occur during acute illnesses where fluid and electrolyte depletion are presentb.Lithium can more commonly cause hyperthyroidism as compared to hypothyroidismc.Renal function should be monitored at least twice yearlyd.Ataxia is a sign of lithium toxicity

A client asks the nurse to explain the meaning of a narrow therapeutic index of a medication. Which information should the nurse use to answer the question?

A 62-year-old man with a history of congestive heart failure (CHF) presents with confusion, nausea, and vomiting. Physical examination reveals peripheral edema, bibasilar crackles, and jugular venous distention. The patient is found to have a sodium level of 112 mEq/L. The physician places the patient on free water restriction. Which of the following laboratory values do you expect with respect to the fractional excretion of sodium (FENa) and urine sodium (UNa) with this condition? FENa UNa(A) >1% <10 mEq/L(B) >1% >20 mEq/L(C) <1% <10 mEq/L(D) <1% >20 mEq/L

A resident of a long-term care facility is taking lithium carbonate to treat bipolar disorder. Which instruction should the nurse provide to this client's caregivers?