Based on its molecular structure, NAPQI most likely damages proteins through which process?A.OxidationB.PhosphorylationC.AcetylationD.Cleavage of carbon-carbon bonds
Question
Based on its molecular structure, NAPQI most likely damages proteins through which process?A.OxidationB.PhosphorylationC.AcetylationD.Cleavage of carbon-carbon bonds
Solution
NAPQI, or N-acetyl-p-benzoquinone imine, is a toxic metabolite of acetaminophen. It is known to cause damage to proteins and other macromolecules primarily through a process known as oxidation. This is because NAPQI is a highly reactive electrophile that can form covalent bonds with nucleophilic sites in proteins, leading to protein dysfunction and cellular damage. Therefore, the answer is A. Oxidation.
Similar Questions
LDH and CYP enzymes are most likely to bind which substrates, respectively?A.NAPQI and APAPB.Lactate and APAPC.NAPQI and GSHD.Lactate and GSH
N-acetylcysteine (NAC) is often administered for the treatment of acetaminophen overdose to help prevent the toxic metabolite, NAPQI, from accumulating in hepatocytes. This is most likely because NAC:Question 33 Answer Choices A. increases the production of NAPQI. B. acts as an inhibitor of glutathione reductase. C. acts to stimulate the action of CYP1A2. D. possesses a, sterically unhindered functional group equivalent to glutathione.
Which of the following amino acid undergoes oxidative deamination?
A protein denatures as ionic interactions are disrupted by deprotonation of positively charged side chains. This is most likely the result of:A.a decrease in the ionic strength of the solution.B.an increase in the ionic strength of the solution.C.a decrease in the pH of the solution.D.an increase in the pH of the solution.
The _____ are responsible for the synthesis and modification of proteins.
Upgrade your grade with Knowee
Get personalized homework help. Review tough concepts in more detail, or go deeper into your topic by exploring other relevant questions.