What is the ideal molecular weight range for an API candidate for a transdermal drug?
Question
What is the ideal molecular weight range for an API candidate for a transdermal drug?
Solution
The ideal molecular weight range for an Active Pharmaceutical Ingredient (API) candidate for a transdermal drug is typically between 150-500 Daltons. This is because molecules of this size are small enough to penetrate the skin barrier, but large enough to carry a sufficient dose of the drug. However, this is not a hard and fast rule, and other factors such as lipophilicity, melting point, and the presence of functional groups can also influence the ability of a molecule to be delivered transdermally.
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