Following intense exercise lactate forms if there is little to no oxygen present. Which statement is TRUE?Select one alternative:Lactate dehydrogenase (LDH) oxidises pyruvate and reduces NADH + H+ to NAD+. At rest the lactate is cleared by the Cori Cycle.Pyruvate dehydrogenase (PDH) reduces pyruvate and oxidises NADH + H+ to NAD+. At rest the lactate is cleared by the Citric Acid Cycle.Lactate dehydrogenase (LDH) oxidises pyruvate and reduces NADH + H+ to NAD+. At rest the lactate is cleared by the Urea Cycle.Lactate dehydrogenase (LDH) reduces pyruvate and oxidises NADH + H+ to NAD+. At rest the lactate is cleared by the Cori Cycle.
Question
Following intense exercise lactate forms if there is little to no oxygen present. Which statement is TRUE?Select one alternative:Lactate dehydrogenase (LDH) oxidises pyruvate and reduces NADH + H+ to NAD+. At rest the lactate is cleared by the Cori Cycle.Pyruvate dehydrogenase (PDH) reduces pyruvate and oxidises NADH + H+ to NAD+. At rest the lactate is cleared by the Citric Acid Cycle.Lactate dehydrogenase (LDH) oxidises pyruvate and reduces NADH + H+ to NAD+. At rest the lactate is cleared by the Urea Cycle.Lactate dehydrogenase (LDH) reduces pyruvate and oxidises NADH + H+ to NAD+. At rest the lactate is cleared by the Cori Cycle.
Solution
The correct statement is: "Lactate dehydrogenase (LDH) reduces pyruvate and oxidises NADH + H+ to NAD+. At rest the lactate is cleared by the Cori Cycle."
This is because LDH catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. In conditions of cellular stress (like intense exercise), LDH reduces pyruvate to lactate, oxidizing NADH to NAD+. When the body is at rest, lactate is converted back to glucose in the liver through the Cori Cycle.
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In lactic acid fermentation, which substance is reduced and which is oxidized?Select one:A.Lactate is reduced and NAD+ is oxidized.B.Pyruvate is reduced and NADH is oxidized.C.Lactate is reduced and pyruvate is oxidized.D.NADH is reduced and pyruvate is oxidized.E.Lactate is oxidized and NADH is reduced.
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