Which of the following statement(s) is(are) TRUE about fluoroquinolone drugs?(A) They contain quinolone ring(s)(B) They inhibit RNA polymerase(C) They bind to bacterial topoisomerase(D) They bind to 23S rRNA within the 50S ribosome subunit
Question
Which of the following statement(s) is(are) TRUE about fluoroquinolone drugs?(A) They contain quinolone ring(s)(B) They inhibit RNA polymerase(C) They bind to bacterial topoisomerase(D) They bind to 23S rRNA within the 50S ribosome subunit
Solution
(A) True - Fluoroquinolones do contain a quinolone ring. This is a central part of their chemical structure.
(B) False - Fluoroquinolones do not inhibit RNA polymerase. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, which are necessary for bacterial DNA replication, transcription, repair, and recombination.
(C) True - As mentioned above, fluoroquinolones bind to bacterial topoisomerase IV and DNA gyrase (topoisomerase II), inhibiting DNA replication and transcription.
(D) False - Fluoroquinolones do not bind to 23S rRNA within the 50S ribosome subunit. This is the mechanism of action for a different class of antibiotics, the macrolides.
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